Genetics is an evolving field, and even though technology has improved in order to identify more disease-causing genetic variants, current laboratory testing strategies still have significant limitations.  Some tests target genetic variants that have been shown to be more common in a specific population group (called founder variants).  The limitation of these tests is that these specific variants may not be more common in all population groups, and therefore these may not be appropriate as a first-line screening test for persons of all genetic ancestries.

Family ancestry in the context of diagnostic genetic testing