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Umbilical Cord Blood Gas Analysis
Cord blood gas analysis is considered the gold standard for the determination of intrapartum foetal hypoxia. It provides an objective retrospective method for continuous quality improvement in the management of foetal acid-base abnormalities. It is also sensible to keep normal blood gas results on record for a baby with an uneventful delivery, but who may develop neurological impairment later.
Lymphocytosis: Causes & approach to evaluation in adults
Lymphocytosis refers to an increase of peripheral blood lymphocytes, which for adults is defined as an absolute lymphocyte count (ALC) > 4.0 x 109 /L. Lymphocytes generally constitute 8-33% of white blood cell count (WBC) in peripheral blood. The normal number and distribution of lymphocyte subsets vary with age.
Mismatch repair, microsatellite instability and germline testing in Lynch Syndrome
Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC), resulting from a germline pathogenic variant in one of the DNA mismatch repair (MMR) genes. The MMR genes associated with LS include MSH2, MLH1, MSH6 and PMS2.