Knowledge Hub

 

   

   What happens @ PathCare?

   Have a look behind the scenes to see how patient specimen

   flow is regulated in our laboratory system.

Respiratory Virus Statistics: Jan – April 2022

The National Institute for Communicable Diseases declared the start of the respiratory syncytial virus (RSV) season in week 7 (week ending 20 February) and the positivity rate has continued to increase through March and April.

Typhoid/Salmonella Testing

Enteric fever includes typhoid fever (an infection caused by Salmonella enterica serotype Typhi) and paratyphoid fever (infections caused by Salmonella enterica subspecies enterica serotypes Paratyphi A, B or rarely, C) Paratyphoid fever is clinically indistinguishable from typhoid fever and the diagnosis and clinical management is identical. In South Africa, enteric fever is a notifiable condition with epidemic potential.

Primary Aldosteronism: An Under-Recognised Problem

Primary aldosteronism (PA), also known as Conn’s syndrome, is common and has a significantly higher cardiovascular risk profile than sex-, age-, and BP-matched patients with essential hypertension. PA is now considered a major public health issue, which requires a concerted effort at case detection through screening, followed by targeted care.

Indeterminate COVID results

The polymerase chain reaction (PCR) test for the detection of SARS-CoV-2 in respiratory specimens is an essential tool in screening and diagnosing COVID-191. Clinical virology laboratories often make use of a diverse repertoire of testing platforms with varying performance characteristics. The high analytical sensitivity of PCR assays often results in low-level detections.

Hyperuricaemia and Gout: Important Lessons to be Learnt

Gout is a common clinical disease and, furthermore, it is readily treatable and managed by the long-term use of urate lowering medication. Gout, the clinical syndrome, needs to be distinguished from hyperuricaemia which refers to the increased levels of serum urate.

Frequently asked questions: SARS-CoV-2 B.1.1.529/Omicron variant

On 26 November 2021 the WHO designated the new SARS-CoV-2 lineage B.1.1.529, now named Omicron, a variant of concern.
Much is still unknown about Omicron and it is expected that the variant’s real world impact will become clearer over the next weeks.

Covid-19 associated pulmonary aspergillosis (CAPA)

In individuals with co-morbidities, defective immune responses to SARS-CoV-2 may allow unrestricted viral replication which elicits hyperinflammation and severe complications such as acute respiratory distress syndrome (ARDS).
COVID-19 resulting in ARDS has recently emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis.

Advances in molecular oncology: Liquid biopsy for non-small cell lung cancer

In recent years, liquid biopsies have emerged as a promising tool in the fields of molecular oncology and precision medicine. Liquid biopsy methodology typically analyses genomic DNA isolated from circulating tumour cells (CTCs) or circulating cell-free tumour DNA (cfDNA/ctDNA) in a peripheral blood sample, to gain insight into the genomic profile of the patients’ tumour.

Polymyxin guidelines

Due to a rapid increase in serious infections related to especially carbapenemase producing Enterobacterales, the clinical use of the polymyxin antibiotics colistin (polymyxin E), and polymyxin B has recently resurged as salvage therapy for otherwise untreatable Gram-negative infections.

Typhoid/Salmonella Testing

Enteric fever includes typhoid fever (an infection caused by Salmonella enterica serotype Typhi) and paratyphoid fever (infections caused by Salmonella enterica subspecies enterica serotypes Paratyphi A, B or rarely, C) Paratyphoid fever is clinically indistinguishable from typhoid fever and the diagnosis and clinical management is identical. In South Africa, enteric fever is a notifiable condition with epidemic potential.

read more

Primary Aldosteronism: An Under-Recognised Problem

Primary aldosteronism (PA), also known as Conn’s syndrome, is common and has a significantly higher cardiovascular risk profile than sex-, age-, and BP-matched patients with essential hypertension. PA is now considered a major public health issue, which requires a concerted effort at case detection through screening, followed by targeted care.

read more

Indeterminate COVID results

The polymerase chain reaction (PCR) test for the detection of SARS-CoV-2 in respiratory specimens is an essential tool in screening and diagnosing COVID-191. Clinical virology laboratories often make use of a diverse repertoire of testing platforms with varying performance characteristics. The high analytical sensitivity of PCR assays often results in low-level detections.

read more

Covid-19 associated pulmonary aspergillosis (CAPA)

In individuals with co-morbidities, defective immune responses to SARS-CoV-2 may allow unrestricted viral replication which elicits hyperinflammation and severe complications such as acute respiratory distress syndrome (ARDS).
COVID-19 resulting in ARDS has recently emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis.

read more

Advances in molecular oncology: Liquid biopsy for non-small cell lung cancer

In recent years, liquid biopsies have emerged as a promising tool in the fields of molecular oncology and precision medicine. Liquid biopsy methodology typically analyses genomic DNA isolated from circulating tumour cells (CTCs) or circulating cell-free tumour DNA (cfDNA/ctDNA) in a peripheral blood sample, to gain insight into the genomic profile of the patients’ tumour.

read more

Polymyxin guidelines

Due to a rapid increase in serious infections related to especially carbapenemase producing Enterobacterales, the clinical use of the polymyxin antibiotics colistin (polymyxin E), and polymyxin B has recently resurged as salvage therapy for otherwise untreatable Gram-negative infections.

read more