Knowledge Hub

Respiratory Pathogen Statistics August 2026

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during August 2026

Vitamin A & E testing now In-house

We are proud to announce that, from 1 September 2026, PathCare will perform Vitamin A (retinol) and Vitamin E (a-tocopherol) testing using HPLC-UV.

CKD Assessment Beyond Creatinine: The role of Cystatin C in the KDIGO CKD 2024 pathway

Cystatin C is a low-molecular-weight protein produced at a relatively constant rate by all nucleated cells. It is freely filtered by the glomeruli and then metabolised in the proximal tubules.

Blood Cancers Awareness Month

This Cancer Awareness Month, we highlight how one of the simplest and most affordable tests in medicine – the full blood count (FBC)- is often the very first clue to a haematological malignancy. 

Respiratory Pathogen Statistics July 2026

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during July 2026

Optimizing TB Diagnostics: Prioritizing Molecular Testing & Culture

The WHO now recommends rapid molecular tests, TB PCR (e.g. GeneXpert), as the initial diagnostic test for all individuals being evaluated for TB, offering improved sensitivity and specificity, rapid identification of MTB and the detection of rifampicin and/or isoniazid resistance.

PMOS: The new name for PCOS and what it means for laboratory assessments

The term PCOS is increasingly recognised as misleading because pathological ovarian cysts are not a defining feature. PMOS better reflects the multysystem endocrine and metabolic nature of the disorder.

Respiratory Pathogen Statistics June 2026

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during June 2026

Testing for Hep B Virus: Information for renal units

Outbreaks of HBV in renal units are still reported, and often there is evidence that these have been caused by lapses in high standards of infection control practice. The most important method of prevention of transmission of blood borne viruses is the rigorous application of universal infection control precautions.

With regard to Designated Service Provider (DSP) Contracts the following law is pertinent for service providers who are not a DSP:

  1. In terms of Section 59 (2) of the Medical Schemes Act 131 of 1998 the medical scheme must pay valid invoices within 30 days of receipt thereof or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct the invoice.
  2. Where services are in respect of medical emergencies or involuntarily obtained services for PMB conditions, the scheme has to pay for the full cost of the services provided without deduction or co-payment or limiting the tariff amount. (Regulation 8 (1) of the Medical Schemes Act no. 131 of 1998.)
  3. DOH notice 214 of 2021 requires that a scheme pays for services provided at the same rate and in terms of the same rules as they pay their DSPs in respect of services voluntarily obtained, whether they are PMBs or not.
  4. The process followed in respect of appointing a DSP is required to be fair, equitable, transparent, competitive or cost effective as required in terms of Notice 214 of the DOH.

In summary:

  1. The law protects the patient’s choice to use their laboratory of choice, even if it is not a DSP, and the scheme is still obliged to reimburse us at the scheme rate for valid claims.
  2. This is true for PMB conditions as well as non-PMB conditions.
  3. The medical scheme must pay valid invoices within 30 days or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct invoice.
  4. A scheme must pay for the services provided at a tariff not less than what they would pay a DSP.
  5. Should any patient have a valid claim rejected because we are not a DSP, we can assist.

 

Flow cytometry for accurate detection and quantitation of fetal maternal haemorrhage

Transplacental or fetomaternal haemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunisation to the D antigen if the mother is D negative and the baby D positive. This can result in haemolytic disease of the fetus and newborn (HDN) in subsequent pregnancies. It is important to assess the volume of FMH to determine the dose of anti-D immunoglobulin (anti-D Ig) required by a D negative woman to prevent sensitisation.

read more

Diagnostic Testing for Autoimmune Liver Diseases

The autoimmune liver diseases include the triad of Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC). These conditions represent perhaps only 5% of all liver diseases, although the true prevalence in South-Africa is uncertain. Autoimmune liver conditions should be considered as a diagnosis after viral, metabolic and drug induced liver injuries have been excluded.

read more

Porphyria Testing Update

The porphyrias arise from enzyme defects in the haem biosynthetic pathway. Accumulation of the precursors (ALA and PBG) lead to acute neurovisceral attacks, marked by severe abdominal pain and autonomic neuropathy, which may progress to a potentially fatal motor neuropathy.

read more

Eastern Cape respiratory surveillance data

Below we present the PathCare susceptibility data for common community-acquired respiratory tract organisms isolated from lower respiratory tract samples of patients in the Eastern Cape during 2018. As this data reflects the susceptibility of all isolates,...

read more

A guide to diarrheagenic E.coli

E. coli is the major aerobic commensal organism in the gut and only causes disease following some disruption of gut, e.g. after penetrating injury. However, a number of E. coli strains or pathotypes possessing particular sets of virulence factors are adapted to cause...

read more

Influenza Update 2019

South Africa carries a heavy influenza burden with more than 12000 deaths each year due to influenza associated severe acute respiratory illness. The most effective strategy to prevent influenza is vaccination.VaccinationAdminister the vaccine each year because the...

read more