Infective endocarditis (IE) is a globally prevalent condition associated with high morbidity and mortality (1,2). Although historically rare, the annual estimated incidence has increased to 13.8 cases per 100 000 patients, attributable to an increased incidence of...
Clostridioides difficile infection (CDI) remains a leading cause of healthcare-associated diarrhoea and antibiotic-associated colitis. C. difficile produces 2 types of toxins; toxins A and B (encoded by TcdA & TcdB genes, respectively), which are virulence factors...
Recent heavy rainfall across South Africa has led to a continued rise in Malaria cases, with high transmission rates persisting in Mpumalanga and Limpopo, and increasing concern around "suitcase" (Odyssean) malaria in non-endemic areas. Vigilance remains...
This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during 2025. As with the monthly respiratory pathogen reports, the data is dependent on submission of samples by clinicians and therefore...
PathCare will now offer simultaneous measurement of salivary cortisol and cortisone using liquid chromatography–high-resolution mass spectrometry (LC-HRMS). This non-invasive, highly specific assay provides an accurate assessment of free cortisol exposure. When...
The Cancer Genome Atlas (TCGA) classifies endometrial cancer into four molecular subtypes: (1) POLE ultra-mutated, (2) Microsatellite unstable, (3) Abnormal p53 expression (p53 Abn) and (4) No specific molecular profile (NSMP), forming the basis of the Proactive...
This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during September 2025 (epidemiological weeks 36-39). The data is dependent on submission of samples by clinicians and therefore may not be...
Laboratory-based data for all GIT molecular panels requested for patients at PathCare laboratories nationally, for the period June to August 2025, are presented in this report. The trends observed for major bacterial and viral pathogens detected from stool samples of...
Linezolid, a synthetic oxazolidinone antibiotic, is frequently used for the treatment of serious gram-positive infections including Staphylococcus aureus and enterococci. It is also commonly used as part of long-term treatment regimens for mycobacterial infections,...
This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during August 2025 (epidemiological weeks 32-35). The data is dependent on submission of samples by clinicians and therefore may not be...