Knowledge Hub

Launch of Salivary Cortisol & Cortisone via LC-HRMS

PathCare will now offer simultaneous measurement of salivary cortisol and cortisone using liquid chromatography–high-resolution mass spectrometry (LC-HRMS).

MOLECULAR SUBTYPING OF ENDOMETRIAL CARCINOMA

Molecular subtyping can assist with predicting treatment outcomes and prognosis of early endometrial cancer and is recommended by the National Comprehensive Cancer Network (NCCN) guidelines.

Respiratory Pathogen Statistics September 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during September 2025

Gastro-Intestinal Pathogen Statistics

Laboratory-based data for all GIT molecular panels requested for patients at PathCare laboratories nationally, for the period June to August 2025, are presented in this report.

The value of therapeutic drug monitoring of linezolid in clinical practice

Linezolid, a synthetic oxazolidinone antibiotic, is frequently used for the treatment of serious gram-positive infections including Staphylococcus aureus and enterococci.

Respiratory Pathogen Statistics August 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during August 2025

The ABC’s of MICs: The value of MIC results in antibiotic treatment decisions

The clinical microbiology laboratory provides valuable susceptibility data that can guide the selection of antibiotic regimens for patients with infections.

Xpert MTB/XDR Testing

PathCare introduces Xpert MTB/XDR testing as a reflex test for rapid molecular drug susceptibility testing of rifampicin-resistant Mycobacterium tuberculosis (RR-TB) positive clinical samples

Respiratory Pathogen Statistics July 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during July 2025

With regard to Designated Service Provider (DSP) Contracts the following law is pertinent for service providers who are not a DSP:

  1. In terms of Section 59 (2) of the Medical Schemes Act 131 of 1998 the medical scheme must pay valid invoices within 30 days of receipt thereof or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct the invoice.
  2. Where services are in respect of medical emergencies or involuntarily obtained services for PMB conditions, the scheme has to pay for the full cost of the services provided without deduction or co-payment or limiting the tariff amount. (Regulation 8 (1) of the Medical Schemes Act no. 131 of 1998.)
  3. DOH notice 214 of 2021 requires that a scheme pays for services provided at the same rate and in terms of the same rules as they pay their DSPs in respect of services voluntarily obtained, whether they are PMBs or not.
  4. The process followed in respect of appointing a DSP is required to be fair, equitable, transparent, competitive or cost effective as required in terms of Notice 214 of the DOH.

In summary:

  1. The law protects the patient’s choice to use their laboratory of choice, even if it is not a DSP, and the scheme is still obliged to reimburse us at the scheme rate for valid claims.
  2. This is true for PMB conditions as well as non-PMB conditions.
  3. The medical scheme must pay valid invoices within 30 days or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct invoice.
  4. A scheme must pay for the services provided at a tariff not less than what they would pay a DSP.
  5. Should any patient have a valid claim rejected because we are not a DSP, we can assist.

 

Lymphocytosis: Causes & approach to evaluation in adults

Lymphocytosis refers to an increase of peripheral blood lymphocytes, which for adults is defined as an absolute lymphocyte count (ALC) > 4.0 x 109 /L. Lymphocytes generally constitute 8-33% of white blood cell count (WBC) in peripheral blood. The normal number and distribution of lymphocyte subsets vary with age.

read more

Flow cytometry for accurate detection and quantitation of fetal maternal haemorrhage

Transplacental or fetomaternal haemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunisation to the D antigen if the mother is D negative and the baby D positive. This can result in haemolytic disease of the fetus and newborn (HDN) in subsequent pregnancies. It is important to assess the volume of FMH to determine the dose of anti-D immunoglobulin (anti-D Ig) required by a D negative woman to prevent sensitisation.

read more

Diagnostic Testing for Autoimmune Liver Diseases

The autoimmune liver diseases include the triad of Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC). These conditions represent perhaps only 5% of all liver diseases, although the true prevalence in South-Africa is uncertain. Autoimmune liver conditions should be considered as a diagnosis after viral, metabolic and drug induced liver injuries have been excluded.

read more

Porphyria Testing Update

The porphyrias arise from enzyme defects in the haem biosynthetic pathway. Accumulation of the precursors (ALA and PBG) lead to acute neurovisceral attacks, marked by severe abdominal pain and autonomic neuropathy, which may progress to a potentially fatal motor neuropathy.

read more