- 1g cefazolin is the right dose for everyone
Weight-based dosing is important to ensure adequate tissue concentrations:
≤ 60 kg 1g
61 -119 kg 2g
≥ 120 kg 3g
Alternatively, 2 grams as a standardised dose will be adequate and safe for most patients
- The timing of administration isn’t important
Dose 30-60 minutes prior to incision to ensure adequate tissue levels when cutting.
If an antibiotic needs prolonged infusion, e.g. vancomycin, one may have to start the infusion 2 hours before surgery.
Common pitfalls in surgical antimicrobial prophylaxis