• 1g cefazolin is the right dose for everyone

Weight-based dosing is important to ensure adequate tissue concentrations:

≤ 60 kg                   1g

61 -119 kg             2g

≥ 120 kg                 3g

Alternatively, 2 grams as a standardised dose will be adequate and safe for most patients

  •  The timing of administration isn’t important

Dose 30-60 minutes prior to incision to ensure adequate tissue levels when cutting.

If an antibiotic needs prolonged infusion, e.g. vancomycin, one may have to start the infusion 2 hours before surgery.

 

Common pitfalls in surgical antimicrobial prophylaxis

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