Knowledge Hub

Launch of Salivary Cortisol & Cortisone via LC-HRMS

PathCare will now offer simultaneous measurement of salivary cortisol and cortisone using liquid chromatography–high-resolution mass spectrometry (LC-HRMS).

MOLECULAR SUBTYPING OF ENDOMETRIAL CARCINOMA

Molecular subtyping can assist with predicting treatment outcomes and prognosis of early endometrial cancer and is recommended by the National Comprehensive Cancer Network (NCCN) guidelines.

Respiratory Pathogen Statistics September 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during September 2025

Gastro-Intestinal Pathogen Statistics

Laboratory-based data for all GIT molecular panels requested for patients at PathCare laboratories nationally, for the period June to August 2025, are presented in this report.

The value of therapeutic drug monitoring of linezolid in clinical practice

Linezolid, a synthetic oxazolidinone antibiotic, is frequently used for the treatment of serious gram-positive infections including Staphylococcus aureus and enterococci.

Respiratory Pathogen Statistics August 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during August 2025

The ABC’s of MICs: The value of MIC results in antibiotic treatment decisions

The clinical microbiology laboratory provides valuable susceptibility data that can guide the selection of antibiotic regimens for patients with infections.

Xpert MTB/XDR Testing

PathCare introduces Xpert MTB/XDR testing as a reflex test for rapid molecular drug susceptibility testing of rifampicin-resistant Mycobacterium tuberculosis (RR-TB) positive clinical samples

Respiratory Pathogen Statistics July 2025

This report is a summary of the results obtained from various molecular respiratory panels performed across PathCare laboratories during July 2025

With regard to Designated Service Provider (DSP) Contracts the following law is pertinent for service providers who are not a DSP:

  1. In terms of Section 59 (2) of the Medical Schemes Act 131 of 1998 the medical scheme must pay valid invoices within 30 days of receipt thereof or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct the invoice.
  2. Where services are in respect of medical emergencies or involuntarily obtained services for PMB conditions, the scheme has to pay for the full cost of the services provided without deduction or co-payment or limiting the tariff amount. (Regulation 8 (1) of the Medical Schemes Act no. 131 of 1998.)
  3. DOH notice 214 of 2021 requires that a scheme pays for services provided at the same rate and in terms of the same rules as they pay their DSPs in respect of services voluntarily obtained, whether they are PMBs or not.
  4. The process followed in respect of appointing a DSP is required to be fair, equitable, transparent, competitive or cost effective as required in terms of Notice 214 of the DOH.

In summary:

  1. The law protects the patient’s choice to use their laboratory of choice, even if it is not a DSP, and the scheme is still obliged to reimburse us at the scheme rate for valid claims.
  2. This is true for PMB conditions as well as non-PMB conditions.
  3. The medical scheme must pay valid invoices within 30 days or advise both the member and service provider of reasons why the invoice is not valid and provide the opportunity to correct invoice.
  4. A scheme must pay for the services provided at a tariff not less than what they would pay a DSP.
  5. Should any patient have a valid claim rejected because we are not a DSP, we can assist.

 

Update on molecular testing for respiratory pathogens

Testing for respiratory pathogens using comprehensive multiplex molecular panels have become a valuable diagnostic tool to assist in early identification of causative organisms. Appropriate use supports timely and directed antimicrobial therapy, especially for organisms that cannot be routinely cultured (e.g Mycoplasma, Legionella, Chlamydophila, Bordetella, and viruses); decreases in-hospital admission rate, length of hospital stay, and also assists in antimicrobial stewardship by avoiding the use of empiric antimicrobial agents

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Diabetes Antibodies

Immune-mediated diabetes is characterized by the presence of circulating specific antibodies against the pancreatic islets such as glutamic acid decarboxylase autoantibodies (GADA), islet antigen-2 autoantibodies (IA-2A), or zinc transporter-8 autoantibodies (ZnT8A).

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Retesting after a positive PCR outcome for SARS-CoV-2

The presence of viral RNA in respiratory samples is critical information in the diagnosis of an acute SARS-COV-2 infection. The real-time reverse transcription-polymerase chain reaction (RT-PCR) detects these pieces of RNA. But RT-PCR is a poor test of cure. The presence of RNA does not imply the presence of infectious or replication-competent virus.

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COVID-19 ANTIBODY TEST

In response to the many questions being asked of us as to when we would be able to offer antibody testing; this is a brief note of explanation as to the processes we have to follow before we may offer the tests.

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Coronavirus

PathCare now offers SARS-CoV-2 / COVID-19 testing

On 31 December 2019, the World Health Organization (WHO) China country office reported a cluster of pneumonia cases in Wuhan City, Hubei Province of China. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been confirmed as the causative virus of Coronavirus disease 2019 (COVID-19). This virus has since spread to all continents and South Africa’s first case was identified on 5 March 2020.

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Umbilical Cord Blood Gas Analysis

Cord blood gas analysis is considered the gold standard for the determination of intrapartum foetal hypoxia. It provides an objective retrospective method for continuous quality improvement in the management of foetal acid-base abnormalities. It is also sensible to keep normal blood gas results on record for a baby with an uneventful delivery, but who may develop neurological impairment later.

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