Knowledge Hub



   What happens @ PathCare?

   Have a look behind the scenes to see how patient specimen

   flow is regulated in our laboratory system.

Umbilical Cord Blood Gas Analysis

Cord blood gas analysis is considered the gold standard for the determination of intrapartum foetal hypoxia. It provides an objective retrospective method for continuous quality improvement in the management of foetal acid-base abnormalities. It is also sensible to keep normal blood gas results on record for a baby with an uneventful delivery, but who may develop neurological impairment later.

Lymphocytosis: Causes & approach to evaluation in adults

Lymphocytosis refers to an increase of peripheral blood lymphocytes, which for adults is defined as an absolute lymphocyte count (ALC) > 4.0 x 109 /L. Lymphocytes generally constitute 8-33% of white blood cell count (WBC) in peripheral blood. The normal number and distribution of lymphocyte subsets vary with age.

Mismatch repair, microsatellite instability and germline testing in Lynch Syndrome

Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC), resulting from a germline pathogenic variant in one of the DNA mismatch repair (MMR) genes.  The MMR genes associated with LS include MSH2, MLH1, MSH6 and PMS2.

Platform change for urine cortisol analysis

Please take note of the platform change for 24 hour urine cortisol analysis.
This test will now be performed on the Abbott Architect immunoassay platform and will result in a change in reference interval to:  
24 hr urine cortisol reference interval: 11.8 – 485.6 nmol/24 hours

Non-payment for syndromic PCR testing (BioFire FilmArray)

We write to you to keep you informed of developments within the medial scheme industry that affect the funding of some tests, specifically BioFire, used for diagnosis in acute respiratory diseases, suspected meningitis/encephalitis and diarrhoeal disease for the rapid identification of the pathogenic cause.

D-Dimer (UG/ML) Change of Method and specimen requirement

The D-Dimer test will be offered on the MINI VIDAS ®.
The report will state on which instrument the D-Dimer test result was obtained.

D-Dimer (NG/ML) Change of Method and specimen requirement

The D-Dimer test will be offered on the MINI VIDAS ®.
The report will state on which instrument the D-Dimer test result was obtained.

Flow cytometry for accurate detection and quantitation of fetal maternal haemorrhage

Transplacental or fetomaternal haemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunisation to the D antigen if the mother is D negative and the baby D positive. This can result in haemolytic disease of the fetus and newborn (HDN) in subsequent pregnancies. It is important to assess the volume of FMH to determine the dose of anti-D immunoglobulin (anti-D Ig) required by a D negative woman to prevent sensitisation.

Diagnostic Testing for Autoimmune Liver Diseases

The autoimmune liver diseases include the triad of Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC). These conditions represent perhaps only 5% of all liver diseases, although the true prevalence in South-Africa is uncertain. Autoimmune liver conditions should be considered as a diagnosis after viral, metabolic and drug induced liver injuries have been excluded.

Iron Deficiency Anaemia in Adults

Iron is an intriguing nutrient with many paradoxical characteristics.  it is the most abundant element on our planet and yet it is hard for living organisms to access due to its very low solubility.  Its ability to switch easily between the ferric and...

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Solid Tumours (Oncomine Focus)

We are pleased to announce the launch our Next Generation Sequencing panel for Solid tumours (Oncomine Focus assay). This has been done in an attempt to improve and streamline our molecular pathology testing offering.  As opposed to testing for single gene...

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ESR on the iSED

Alternate or modified Westergren methods to measure erythrocyte sedimentation rate (ESR) have been adopted by laboratories worldwide. These methods offer reduction in analysis time and improved operator safety. The iSED Erythrocyte Sedimentation Rate...

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Hepatitis B and Pregnancy

Acute Viral Hepatitis is the most common cause of jaundice in pregnancy.  HBV infection during pregnancy is usually mild, not associated with increased mortality or teratogenicity, and should not prompt consideration of termination.  Acute HBV infection...

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Rapid Identification of Blood Cultures

Pathcare Reference Laboratory has recently instituted a rapid blood culture ID technique where organisms from positive blood cultures can now be identified after about 4 hours from the time when the blood culture system flags the blood culture bottle as positive.

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