Knowledge Hub



   What happens @ PathCare?

   Have a look behind the scenes to see how patient specimen

   flow is regulated in our laboratory system.

Sweat Test for CF

A sweat test measures the amount of salt in the sweat of the patient. It is used to diagnose cystic fibrosis (CF). Patients with CF have high levels of salt in their sweat. CF is a disease that causes mucus build-up in the lungs and other organs. It damages the lungs and makes it
difficult to breathe.

Update on Laboratory testing of Ophthalmology Samples

Key considerations:A key issue is the small volume of sample that is available.  It is not feasible to perform all tests on all samples whilst maintaining optimum sensitivity.Therefore, it is the clinician's responsibility to prioritise testing for each...

Eastern Cape respiratory surveillance data

Below we present the PathCare susceptibility data for common community-acquired respiratory tract organisms isolated from lower respiratory tract samples of patients in the Eastern Cape during 2018. As this data reflects the susceptibility of all isolates,...

A guide to diarrheagenic E.coli

E. coli is the major aerobic commensal organism in the gut and only causes disease following some disruption of gut, e.g. after penetrating injury. However, a number of E. coli strains or pathotypes possessing particular sets of virulence factors are...

Influenza Update 2019

South Africa carries a heavy influenza burden with more than 12000 deaths each year due to influenza associated severe acute respiratory illness. The most effective strategy to prevent influenza is vaccination.VaccinationAdminister the vaccine each year...

Genetic testing for hereditary colorectal and endometrial cancer

Approximately 10% of all colorectal cancers (CRC) are hereditary.  Patients who carry a pathogenic germline variant in a CRC-related gene have an increased risk to develop CRC, as well as other cancers.  Genetic testing may confirm a diagnosis and help...

Genetic testing for hereditary prostate cancer

Nearly 1 in 6 prostate cancer patients has a germline disease-causing genetic variant. A recent study in JAMA Oncology examining 3607 men with a personal history of prostate cancer has found that 17% had a germline disease-causing genetic variant.  This...

Iron Deficiency Anaemia in Adults

Iron is an intriguing nutrient with many paradoxical characteristics.  it is the most abundant element on our planet and yet it is hard for living organisms to access due to its very low solubility.  Its ability to switch easily between the ferric and...

Solid Tumours (Oncomine Focus)

We are pleased to announce the launch our Next Generation Sequencing panel for Solid tumours (Oncomine Focus assay). This has been done in an attempt to improve and streamline our molecular pathology testing offering.  As opposed to testing for single gene...

ESR on the iSED

Alternate or modified Westergren methods to measure erythrocyte sedimentation rate (ESR) have been adopted by laboratories worldwide. These methods offer reduction in analysis time and improved operator safety. The iSED Erythrocyte Sedimentation Rate...

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Hepatitis B and Pregnancy

Acute Viral Hepatitis is the most common cause of jaundice in pregnancy.  HBV infection during pregnancy is usually mild, not associated with increased mortality or teratogenicity, and should not prompt consideration of termination.  Acute HBV infection...

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Rapid Identification of Blood Cultures

Pathcare Reference Laboratory has recently instituted a rapid blood culture ID technique where organisms from positive blood cultures can now be identified after about 4 hours from the time when the blood culture system flags the blood culture bottle as positive.

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