Knowledge Hub



   What happens @ PathCare?

   Have a look behind the scenes to see how patient specimen

   flow is regulated in our laboratory system.

D-Dimer (UG/ML) Change of Method and specimen requirement

The D-Dimer test will be offered on the MINI VIDAS ®.
The report will state on which instrument the D-Dimer test result was obtained.

D-Dimer (NG/ML) Change of Method and specimen requirement

The D-Dimer test will be offered on the MINI VIDAS ®.
The report will state on which instrument the D-Dimer test result was obtained.

Flow cytometry for accurate detection and quantitation of fetal maternal haemorrhage

Transplacental or fetomaternal haemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunisation to the D antigen if the mother is D negative and the baby D positive. This can result in haemolytic disease of the fetus and newborn (HDN) in subsequent pregnancies. It is important to assess the volume of FMH to determine the dose of anti-D immunoglobulin (anti-D Ig) required by a D negative woman to prevent sensitisation.

Diagnostic Testing for Autoimmune Liver Diseases

The autoimmune liver diseases include the triad of Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC). These conditions represent perhaps only 5% of all liver diseases, although the true prevalence in South-Africa is uncertain. Autoimmune liver conditions should be considered as a diagnosis after viral, metabolic and drug induced liver injuries have been excluded.

Genetic Counselling: Understanding Genetics Together

Genetic counselling provides people with information about genetics and risks, the benefits, possibilities and limitations of genetic testing, potential outcomes of testing and management options.

Genetics International Referral Service

Your doctor/genetic counsellor has ordered an Invitae genetic test for you or your child through PathCare.  invitae Laboratory, based in the USA, will be performing your testing and PathCare is here to coordinate the process.  The attached information will guide you through the process.

Porphyria Testing Update

The porphyrias arise from enzyme defects in the haem biosynthetic pathway. Accumulation of the precursors (ALA and PBG) lead to acute neurovisceral attacks, marked by severe abdominal pain and autonomic neuropathy, which may progress to a potentially fatal motor neuropathy. Accumulation of the porphyrins lead to photocutaneous sensitivity, which presents with skin fragility, blistering and erosions in sun-exposed areas.

Sweat Test for CF

A sweat test measures the amount of salt in the sweat of the patient. It is used to diagnose cystic fibrosis (CF). Patients with CF have high levels of salt in their sweat. CF is a disease that causes mucus build-up in the lungs and other organs. It damages the lungs and makes it
difficult to breathe.

Update on Laboratory testing of Ophthalmology Samples

Key considerations:A key issue is the small volume of sample that is available.  It is not feasible to perform all tests on all samples whilst maintaining optimum sensitivity.Therefore, it is the clinician's responsibility to prioritise testing for each...

Eastern Cape respiratory surveillance data

Below we present the PathCare susceptibility data for common community-acquired respiratory tract organisms isolated from lower respiratory tract samples of patients in the Eastern Cape during 2018. As this data reflects the susceptibility of all isolates,...

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A guide to diarrheagenic E.coli

E. coli is the major aerobic commensal organism in the gut and only causes disease following some disruption of gut, e.g. after penetrating injury. However, a number of E. coli strains or pathotypes possessing particular sets of virulence factors are...

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Influenza Update 2019

South Africa carries a heavy influenza burden with more than 12000 deaths each year due to influenza associated severe acute respiratory illness. The most effective strategy to prevent influenza is vaccination.VaccinationAdminister the vaccine each year...

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Iron Deficiency Anaemia in Adults

Iron is an intriguing nutrient with many paradoxical characteristics.  it is the most abundant element on our planet and yet it is hard for living organisms to access due to its very low solubility.  Its ability to switch easily between the ferric and...

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Solid Tumours (Oncomine Focus)

We are pleased to announce the launch our Next Generation Sequencing panel for Solid tumours (Oncomine Focus assay). This has been done in an attempt to improve and streamline our molecular pathology testing offering.  As opposed to testing for single gene...

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